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KMID : 0895420020120020135
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Journal of Korean Society of Occupational and Enviromental Hygiene
2002 Volume.12 No. 2 p.135 ~ p.139
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Biological monitoring for acrylonitrile workers in fiber sizing agent workplaces
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양정선/Yang, Jeong Sun
변상훈/강성규/박인정/Byeon, Sang Hoon/Kang, Seong-Kyu/Park, In Jeong
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Abstract
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The purpose of this study was to investigate the level of acrylonitrile(AN) exposure in workplace air and body burden of AN as a form of hemoglobin adduct.
The mean of AN concentration of 10 workplaces was 0.24ppm(GSD 4.80) which was under TLV(2ppm). But 7% of 140 measurements and 5 of 10 workplace was over TLV.
The GM of hemoglobin adduct detected with cyanoethy-Ibaline(CE) in 110 biological monitoring was 1.51nmol/g globin(GSD 3.43).
The correlation coefficient between AN concentration in the workplace air and the amount of hemoglobin adduct measured by CE concentration was 0.56. And the equation showed y= 2069.1 + 1861.2. If 2ppm of airborne AN TLV insert to that equation, the concentration of hemoglobin adduct detected with cyanoethlvaline is 6.0nmol/g globin and this value means biological indices(BELs) of ACGIH. 8% of workers showed over 6.00nmol/g globin.
For most of workers were exposed to AN intermittently according to their special assignment of that day, ambient monitoring for a day could not effectively represent their body burden. And it was very good compensation for ambient monitoring to evaluate each worker´s cumulative exposure by biological monitoring of hemoglobin adduct detected with cyanoethylbaline.
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